DIANABOL - Methandrostenolone, INDIA @ 09884425000

DIANABOL - Methandrostenolone  @ 09884425000

Methandrostenolone  (trade names Averbol, Dianabol, Danabol), also known as methandienone, or informally as dianabol, is an orally-effective anabolic steroids originally developed in Germany and released in the US in the early 1960s by Ciba Specialty Chemicals.Methandrostenolone is a controlled substance in the United States and Western Europe and remains popular among bodybuilders. An injectable form is sold online from United States based companies. Methandrostenolone is readily available without a prescription in countries such as Mexico (under the trade name Reforvit-b), and is also being manufactured in Asia and many East European countries.

 Methandrostenolone - Dianabol 

Despite the lack of any known therapeutic applications, the drug remained legal until 2001.The United States Congress added certain kinds of steroids which may or may not include methandrostenolone to the Controlled Substances Act as an amendment known as the Anabolic Steroid Control Act of 1990. This act placed steroids in the same category as some amphetamines as a "Schedule III" drug and possession of these drugs results in a felony. It is used by bodybuilders and methandrostenolone continues to be used illegally to this day, typically being combined (stacked) with injectable compounds, such as testosterone propionate, enanthate, cypionate as well as other injectable drugs like trenbolone acetate.
Several successful athletes and professional bodybuilders have come forward and admitted long-term methandrostenolone use before the drug was banned, including Arnold Schwarzenegger. Other steroids stacked with methandrostenolone are primarily, if not always, injectable compounds such as testosterone, trenbolone and nandrolone. Large doses and long-term use of methandrostenolone have been associated with eccentric left ventricular hypertrophy which presents substantially increased risks of cardiomyopathy if and when the hypertrophy atrophies. Athleticism is typically associated with left-ventricular hypertrophy however natural athleticism generally presents concentric left ventricular growth which is not linked to an increased risk of cardiomyopathy.

Cycles and Dianabol Dosages

While Dianabol is most appropriate and most commonly used for gaining strength and size in bulking cycles, it is possible to use it effectively in cutting cycles. That said, because it is mostly used for bulking, that is the use that we will focus on here. It is an oral steroid that takes effect rapidly and has a short half life of about 5-6 hours to match. This makes Dianabol one of the fastest acting and shortest lived steroids available.
Because it works so quickly, most users like to use Dianabol doses for a few weeks at the beginning of a steroid cycle to kickstart results. Though kickstarting cycles is the most common use of Dianabol, some users will take it in order to help break through plateaus when size and strength gains begin to slow down. Experienced competitive bodybuilders will use it to kickstart a cycle, and again later to bust through a plateau. 

Between 20mg and 50mg a Day for Beginners

When it comes to dosing, there are no hard and fast rules, but 20 milligrams is the minimum needed by most male athletes to see results. The maximum dose for most athletes is about 50 milligrams of Dianabol, but some highly seasoned and daring users will go as high as 100 milligrams per day. Though 100 mg is generally regarded as safe, but most users will get great results at a maximum daily dose of 50 mg. Keep in mind, however, that this is assuming the product you get is genuine.
For beginning users, a starting dose of 20-30 mg per day is suggested. This range gives great results, but is still low enough to minimize side effects and to give the user a chance to find out how the steroid affects their individual physiology. It is crucial with any anabolic steroid for new users to start with low doses in order to gauge their individual reaction and tolerance to the specific steroid. Not only this, some users may even find that the low DBol dose is all they ever need to get the results they need.

Unwanted Dianabol Side Effects

Though Dianabol can be liver toxic, it is possible to not only avoid actual liver damage but to return liver enzymes to normal levels provided the steroid is used responsibly, at recommended doses and in cycles not to exceed six weeks at a time.
While liver toxicity is a concern, an even greater concern is the tendency to elevate blood pressure. Individuals who are prone to high blood pressure should avoid using Dianabol unless and until their blood pressure is well managed. Although elevated blood pressure is one of the more common side effects of Dianabol, many users will not have a problem, even at doses on the higher end of the spectrum. Unless you have existing high blood pressure, it really is impossible to tell whether and to what degree it might affect you.
The next common issue with Dianabol is that it aromatizes and converts to estrogen. This makes it necessary for users to watch out for estrogenic side effects such as gynecomastia. To avoid this, many users will include an aromatase inhibitor like Arimidex or Letrozole.
Finally, Dianabol inhibits the body’s ability to produce natural testosterone and most users will counteract this by supplementing with injectable testosterone in order to maintain normal levels of the hormone. Most users get a tremendous advantage from taking Dianabol and testosterone together in a stack.

Detection of use:-

Methandrostenolone is subject to extensive hepatic biotransformation by a variety of enzymatic pathways. The primary urinary metabolites are detectable for up to 3 days, and a recently discovered hydroxymethyl metabolite is found in urine for up to 19 days after a single 5 mg oral dose. Several of the metabolites are unique to methandrostenolone. Methods for detection in urine specimens usually involve gas chromatography-mass spectrometry.

Anabolic and androgenic effects

Anabolic and androgenic effects

As the name suggests, anabolic-androgenic steroids have two different, but overlapping, types of effects: anabolic, meaning that they promote anabolism (cell growth), and androgenic (or virilising), meaning that they affect the development and maintenance of masculine characteristics.
Some examples of the anabolic effects of these hormones are increased protein synthesis from amino acids, increased appetite, increased bone remodeling and growth, and stimulation of bone marrow, which increases the production of red blood cells. Through a number of mechanisms anabolic steroids stimulate the formation of muscle cells and hence cause an increase in the size of skeletal muscles, leading to increased strength.
The androgenic effects of AAS are numerous. Depending on the length of use, the side effects of the steroid can be irreversible. Processes affected include pubertal growth, sebaceous gland oil production, and sexuality (especially in fetal development). Some examples of virilizing effects are growth of the clitoris in females and the penis in male children (the adult penis size does not change due to steroids[medical citation needed] ), increased vocal cord size, increased libido, suppression of natural sex hormones, and impaired production of sperm. Effects on women include deepening of the voice, facial hair growth, and possibly a decrease in breast size. Men may develop an enlargement of breast tissue, known as gynecomastia, testicular atrophy, and a reduced sperm count.
The androgenic:anabolic ratio of an AAS is an important factor when determining the clinical application of these compounds. Compounds with a high ratio of androgenic to an anabolic effects are the drug of choice in androgen-replacement therapy (e.g., treating hypogonadism in males), whereas compounds with a reduced androgenic:anabolic ratio are preferred for anemia and osteoporosis, and to reverse protein loss following trauma, surgery, or prolonged immobilization. Determination of androgenic:anabolic ratio is typically performed in animal studies, which has led to the marketing of some compounds claimed to have anabolic activity with weak androgenic effects. This disassociation is less marked in humans, where all anabolic steroids have significant androgenic effects.
A commonly used protocol for determining the androgenic:anabolic ratio, dating back to the 1950s, uses the relative weights of ventral prostate (VP) and levator ani muscle (LA) of male rats. The VP weight is an indicator of the androgenic effect, while the LA weight is an indicator of the anabolic effect. Two or more batches of rats are castrated and given no treatment and respectively some AAS of interest. The LA/VP ratio for an AAS is calculated as the ratio of LA/VP weight gains produced by the treatment with that compound using castrated but untreated rats as baseline: (LAc,t–LAc)/(VPc,t–VPc). The LA/VP weight gain ratio from rat experiments is not unitary for testosterone (typically 0.3–0.4), but it is normalized for presentation purposes, and used as basis of comparison for other AAS, which have their androgenic:anabolic ratios scaled accordingly (as shown in the table above). In the early 2000s, this procedure was standardized and generalized throughout OECD in what is now known as the Hershberger assay.

Body composition and strength improvements

A review spanning more than three decades of experimental studies in men found that body weight may increase by 2–5 kg as a result of short-term (<10 weeks) AAS use, which may be attributed mainly to an increase of lean mass. Animal studies also found that fat mass was reduced, but most studies in humans failed to elucidate significant fat mass decrements. The effects on lean body mass have been shown to be dose-dependent. Both muscle hypertrophy and the formation of new muscle fibers have been observed. The hydration of lean mass remains unaffected by AAS use, although small increments of blood volume cannot be ruled out.
The upper region of the body (thorax, neck, shoulders, and upper arm) seems to be more susceptible for AAS than other body regions because of predominance of androgen receptors in the upper body. The largest difference in muscle fiber size between AAS users and non-users was observed in type I muscle fibers of the vastus lateralis and the trapezius muscle as a result of long-term AAS self-administration. After drug withdrawal, the effects fade away slowly, but may persist for more than 6–12 weeks after cessation of AAS use.
The same review observed strength improvements in the range of 5–20% of baseline strength, depending largely on the drugs and dose used as well as the administration period. Overall, the exercise where the most significant improvements were observed is the bench press. For almost two decades, it was assumed that AAS exerted significant effects only in experienced strength athletes, particularly based on the studies of Hervey and coworkers. In 1996, a randomized controlled trial published in the New England Journal of Medicine demonstrated, however, that even in novice athletes a 10-week strength training program accompanied by testosterone enanthate at 600 mg/week may improve strength more than training alone does. The same study found that dose to be sufficient to significantly improve lean muscle mass relative to placebo even in subjects that did not exercise at all. A 2001 study by the same first author, showed that the anabolic effects of testosterone enanthate were highly dose dependent.

Mechanism and Action

The human androgen receptor bound to testosterone. The protein is shown as a ribbon diagram in red, green, and blue, with the steroid shown in white.
The pharmacodynamics of anabolic steroids are unlike peptide hormones. Water-soluble peptide hormones cannot penetrate the fatty cell membrane and only indirectly affect the nucleus of target cells through their interaction with the cell’s surface receptors. However, as fat-soluble hormones, anabolic steroids are membrane-permeable and influence the nucleus of cells by direct action. The pharmacodynamic action of anabolic steroids begin when the exogenous hormone penetrates the membrane of the target cell and binds to an androgen receptor located in the cytoplasm of that cell. From there, the compound hormone-receptor diffuses into the nucleus, where it either alters the expression of genes or activates processes that send signals to other parts of the cell. Different types of anabolic steroids bind to the androgen receptor with different affinities, depending on their chemical structure.Some anabolic steroids such as methandrostenolone bind weakly to this receptor in vitro, but still exhibit androgenic effects in vivo. The reason for this discrepancy is not known.
The effect of anabolic steroids on muscle mass is caused in at least two ways: first, they increase the production of proteins; second, they reduce recovery time by blocking the effects of stress hormone cortisol on muscle tissue, so that catabolism of muscle is greatly reduced. It has been hypothesized that this reduction in muscle breakdown may occur through anabolic steroids inhibiting the action of other steroid hormones called glucocorticoids that promote the breakdown of muscles. Anabolic steroids also affect the number of cells that develop into fat-storage cells, by favouring cellular differentiation into muscle cells instead. Anabolic steroids can also decrease fat by increasing basal metabolic rate (BMR), since an increase in muscle mass increases BMR.

ANABOLIC ADMINISTRATION

Anabolic Administration

There are four common forms in which anabolic steroids are administered: oral pills; injectable steroids; creams/gels for topical application; and skin patches. Oral administration is the most convenient. Testosterone administered by mouth is rapidly absorbed, but it is largely converted to inactive metabolites, and only about 1/6 is available in active form. In order to be sufficiently active when given by mouth, testosterone derivatives are alkylated at the 17 position, e.g. methyltestosterone and fluoxymesterone. This modification reduces the liver's ability to break down these compounds before they reach the systemic circulation.

Testosterone can be administered parenterally, but it has more irregular prolonged absorption time and greater activity in propionate, enanthate, undecanoate, or cypionate ester form. These derivatives are hydrolyzed to release free testosterone at the site of injection; absorption rate (and thus injection schedule) varies among different esters, but medical injections are normally done anywhere between semi-weekly to once every 12 weeks. A more frequent schedule may be desirable in order to maintain a more constant level of hormone in the system. Injectable steroids are typically administered into the muscle, not into the vein, to avoid sudden changes in the amount of the drug in the bloodstream. In addition, because estered testosterone is dissolved in oil, intravenous injection has the potential to cause a dangerous embolism (clot) in the bloodstream.

Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream. Testosterone-containing creams and gels that are applied daily to the skin are also available, but absorption is inefficient (roughly 10%, varying between individuals) and these treatments tend to be more expensive. Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed. There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering anabolic steroids for non-medical purposes.
The traditional routes of administration do not have differential effects on the efficacy of the drug. Studies indicate that the anabolic properties of anabolic steroids are relatively similar despite the differences in pharmacokinetic principles such as first-pass metabolism. However, the orally available forms of AAS may cause liver damage in high doses.

List & Types Of Steroids

List & Types Of Steroids

Exogenous anabolic androgenic steroids
    1-Androstenediol
    1-Androstenedione
    Bolandiol
    Bolasterone
    Boldenone
    Boldione
    Calusterone
    Clostebol
    Danazol
    Dehydrochlormethyltestosterone
    Desoxymethyltestosterone
    Drostanolone
    Ethylestrenol
    Fluoxymesterone
    Formebolone
    Furazabol
    Gestrinone
    4-Hydroxytestosterone
    Mestanolone
    Mesterolone
    Metenolone
    Methandienone
    Methandriol
   Methasterone
    Methyldienolone
    Methyl-1-testosterone
    Methylnortestosterone
    Methyltestosterone
    Metribolone
    Mibolerone
    Nandrolone
    19-Norandrostenedione
    Norboletone
    Norclostebol
    Norethandrolone
    Oxabolone
    Oxandrolone
    Oxymesterone
    Oxymetholone
    Prostanozol
    Quinbolone
    Stanozolol
    Stenbolone
    1-Testosterone
    Tetrahydrogestrinone
    Trenbolone

Endogenous anabolic androgenic steroids:
    Androstenediol
    Androstenedione
    Dihydrotestosterone
    Prasterone (dehydroepiandrosterone DHEA)
    Testosterone

Metabolites and isomers
Metabolites and isomers of endogenous anabolic androgenic steroids, including, but not limited to:
    5α-Androstane-3α,17α-diol
    5α-Androstane-3α,17β-diol
    5α-Androstane-3β,17α-diol
    5α-Androstane-3β,17β-diol
    Androst-4-ene-3α,17α-diol
    Androst-4-ene-3α,17β-diol
    Androst-4-ene-3β,17α-diol
    Androst-4-ene-3β,17α-diol
    Androst-5-ene-3α,17α-diol
    Androst-5-ene-3α,17β-diol
    Androst-5-ene-3β,17α-diol
    4-Androstenediol
    5-Androstenedione
    Epi-dihydrotestosterone
    Epitestosterone
    3α-Hydroxy-5α-androstan-17-one
    3β-Hydroxy-5α-androstan-17-one
    7α-Hydroxy-DHEA
    7β-Hydroxy-DHEA
    7-Keto-DHEA
    19-Norandrosterone
    19-Noretiocholanolone

Steroids - In and Out

Anabolic steroids, technically known as anabolic-androgenic steroids (AAS), are drugs that are structurally related to the cyclic steroid ring system and have similar effects to testosterone in the body. They increase protein within cells, especially in skeletal muscles. Anabolic steroids also have androgenic and virilizing properties, including the development and maintenance of masculine characteristics such as the growth of the vocal cords, testicles (primary sexual characteristics) and body hair (secondary sexual characteristics). The word anabolic comes from the Greek ἀναβολή anabole, "that which is thrown up, mound", and the word androgenic from the Greek ἀνδρός andros, "of a man" + -γενής -genes, "born".
Anabolic steroids were first made in the 1930s, and are now used therapeutically in medicine to stimulate bone growth and appetite, induce male puberty and treat chronic wasting conditions, such as cancer and AIDS. The American College of Sports Medicine acknowledges that AAS, in the presence of adequate diet, can contribute to increases in body weight, often as lean mass increases and that the gains in muscular strength achieved through high-intensity exercise and proper diet can be additionally increased by the use of AAS in some individuals.
Health risks can be produced by long-term use or excessive doses of anabolic steroids.These effects include harmful changes in cholesterol levels (increased low-density lipoprotein and decreased high-density lipoprotein), acne, high blood pressure, liver damage (mainly with oral steroids), and dangerous changes in the structure of the left ventricle of the heart. Conditions pertaining to hormonal imbalances such as gynecomastia and testicular atrophy may also be caused by anabolic steroids.
Ergogenic uses for anabolic steroids in sports, racing, and bodybuilding as performance-enhancing drugs are controversial because of their adverse effects and the potential to gain unfair advantage is considered cheating. Their use is referred to as doping and banned by all major sporting bodies. For many years, AAS have been by far the most detected doping substances in IOC-accredited laboratories. In countries where AAS are controlled substances, there is often a black market in which smuggled, clandestinely manufactured or even counterfeit drugs are sold to users.